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What is immune system

    Home TB Information What is immune system
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    What is immune system

    By rajivtbai | TB Information | 12,325 comments | 18 January, 2020 | 0

    Immune system in Hindi

    Immune system, प्रतिरक्षा प्रणाली, ऊतकों, कोशिकाओं और अणुओं से बनी होती है, जो सभी मिलकर एक प्रतिरक्षा प्रतिक्रिया उत्पन्न करने के लिए काम करते हैं जो हमें सूक्ष्मजीवों से बचाता है, विषाक्त पदार्थों को निकालता है, और ट्यूमर कोशिकाओं को नष्ट करता है – उम्मीद है कि एक बार में सभी नहीं! प्रतिरक्षा प्रतिक्रिया एक खतरे की पहचान कर सकती है, एक हमले को माउंट कर सकती है, एक रोगज़नक़ को समाप्त कर सकती है, और अपराधी को याद करने के लिए तंत्र विकसित कर सकती है अगर आप इसे फिर से मुठभेड़ करते हैं – सभी 10 दिनों के भीतर।

     

     

    How to work Immune system 

    कुछ मामलों में, जैसे कि रोगज़नक़ विशेष रूप से जिद्दी है या यदि प्रतिरक्षा प्रणाली कुछ पर हमला करना शुरू कर देती है, तो यह आपके ऊतक की तरह नहीं होना चाहिए, यह बहुत लंबे समय तक, महीनों तक रह सकता है, और इससे पुरानी सूजन हो सकती है। आपकी प्रतिरक्षा प्रणाली सेना की तरह है – दो मुख्य शाखाओं के साथ, जन्मजात प्रतिरक्षा प्रतिक्रिया और अनुकूली प्रतिरक्षा प्रतिक्रिया। जन्मजात प्रतिरक्षा प्रतिक्रिया में ऐसी कोशिकाएं शामिल होती हैं जो गैर-विशिष्ट होती हैं, जिसका अर्थ है कि यद्यपि वे एक मानव कोशिका से एक हमलावर को अलग करती हैं, वे एक हमलावर को दूसरे हमलावर से अलग नहीं करती हैं। सहज प्रतिक्रिया भी तेजी से बुखार है – मिनट से घंटे के भीतर काम करना। उसे ले लो? “फेवरिशली” – क्योंकि यह बुखार पैदा करने के लिए जिम्मेदार है। उस गति के लिए व्यापार बंद है कि जन्मजात प्रतिक्रियाओं के साथ कोई स्मृति जुड़ी नहीं है।

    दूसरे शब्दों में, जन्मजात प्रतिक्रिया ठीक उसी तरह से उसी रोगज़नक़ पर प्रतिक्रिया करेगी, चाहे वह कितनी बार रोगज़नक़ को देखता हो। जन्मजात प्रतिरक्षा प्रतिक्रिया में ऐसी चीजें शामिल हैं जो आप प्रतिरक्षा प्रणाली का हिस्सा होने के बारे में सोच भी नहीं सकते हैं। रासायनिक अवरोध जैसी चीजें, आँसू में लाइसोजाइम और पेट में कम पीएच, साथ ही त्वचा और आंत में उपकला जैसे शारीरिक अवरोध, और सिलिया जो वायुमार्ग को आक्रमणकारियों को बाहर रखने के लिए पंक्तिबद्ध करते हैं। इसके विपरीत, प्रत्येक आक्रमणकारी के लिए अनुकूली प्रतिरक्षा प्रतिक्रिया अत्यधिक विशिष्ट होती है। अनुकूली प्रतिरक्षा प्रतिक्रिया की कोशिकाओं में रिसेप्टर्स होते हैं जो अपने अद्वितीय भागों द्वारा एक रोगज़नक़ को अलग करते हैं – जिसे एंटीजन कहा जाता है। ये रिसेप्टर्स अनुकूल बैक्टीरिया और संभावित रूप से घातक लोगों के बीच अंतर कर सकते हैं। व्यापार बंद यह है कि अनुकूली प्रतिक्रिया कोशिकाओं के प्राइमेड या सक्रिय होने पर निर्भर करती है, इसलिए वे उस रोगज़नक़ को मारने के लिए सही तरह के फाइटर में पूरी तरह से अंतर कर सकते हैं, और इसमें कुछ सप्ताह लग सकते हैं। लेकिन अनुकूली प्रतिरक्षा प्रतिक्रिया का महान लाभ इम्यूनोलॉजिकल मेमोरी है। अनुकूली प्रतिरक्षा प्रतिक्रिया में सक्रिय होने वाली कोशिकाएं क्लोनल विस्तार से गुजरती हैं जिसका अर्थ है कि वे व्यापक रूप से प्रसार करते हैं।

    और हर बार जब अनुकूली कोशिकाएं उसी रोगज़नक़ को देखती हैं, तो वे बड़े पैमाने पर फिर से फैलती हैं, जिसके परिणामस्वरूप हर बार एक मजबूत और तेज़ प्रतिक्रिया होती है जो कि रोगज़नक़ के आसपास आती है। एक बार जब रोगज़नक़ नष्ट हो जाता है, तो अधिकांश क्लोन की गई कोशिकाएँ समाप्त हो जाती हैं, जिसे क्लोनल विलोपन कहा जाता है। लेकिन कुछ क्लोन किए गए विस्तृत सेल मेमोरी सेल के रूप में रहते हैं और वे उस रोगज़नक़ को फिर से जीवित करने के लिए एक बार और विस्तार करने के लिए तैयार हैं। अब, सैनिकों से मिलने का समय है – जो सफेद रक्त कोशिकाओं या ल्यूकोसाइट्स हैं। हेमटोपोइजिस सफेद रक्त कोशिकाओं, साथ ही लाल रक्त कोशिकाओं, और प्लेटलेट्स बनाने की प्रक्रिया है और यह अस्थि मज्जा में होता है। हेमटोपोइजिस एक बहुपत्नी हेमटोपोइएटिक स्टेम सेल से शुरू होता है जो विभिन्न सेल प्रकारों में विकसित हो सकता है – यह भविष्य अनिर्णीत है। कुछ मायलॉइड पूर्वज कोशिका बन जाते हैं जबकि अन्य लिम्फोइड पूर्वज कोशिका बन जाते हैं। माइलॉयड पूर्वज कोशिकाएं मायलोइड कोशिकाओं में विकसित होती हैं, जिसमें न्यूट्रोफिल, ईोसिनोफिल, बेसोफिल, मस्तूल कोशिकाएं, डेंड्रिटिक कोशिकाएं, मैक्रोफेज और मोनोसाइट्स शामिल हैं, ये सभी सहज प्रतिरक्षा प्रतिक्रिया का हिस्सा हैं और रक्त के साथ-साथ ऊतकों में भी पाए जा सकते हैं। । न्यूट्रोफिल, ईोसिनोफिल, बेसोफिल और मस्तूल कोशिकाओं को ग्रैन्यूलोसाइट्स माना जाता है, क्योंकि उनके साइटोप्लाज्म में दाने होते हैं, और न्यूट्रोफिल, ईोसिनोफिल और बेसोफिल की तिकड़ी को पॉलीमोर्फोन्यूक्लियर सेल या पीएमएन भी कहा जाता है, क्योंकि वे नाभिक होते हैं जिसमें कई लॉब होते हैं। गोल होने के बजाय। मस्तूल कोशिकाओं को पीएमएन नहीं माना जाता है क्योंकि उनका नाभिक गोल होता है।

    प्रतिरक्षा प्रतिक्रिया के दौरान, अस्थि मज्जा बहुत सारे पीएमएन उत्पन्न करता है, जिनमें से अधिकांश न्यूट्रोफिल होते हैं। न्यूट्रोफिल एक प्रक्रिया का उपयोग करता है जिसे फैगोसाइटोसिस कहा जाता है – जहां वे एक रोगज़नक़ के पास पहुंचते हैं और अपने साइटोप्लाज्म के साथ इसे “निगल” करने के लिए चारों ओर पहुंचते हैं ताकि यह एक फागोसोम में समाप्त हो जाए। वहां से, न्यूट्रोफिल दो तरीकों का उपयोग करके रोगज़नक़ को नष्ट कर सकते हैं – वे अपने साइटोप्लाज्मिक ग्रैन्यूल या ऑक्सीडेटिव फट का उपयोग कर सकते हैं। सबसे पहले, साइटोप्लाज्मिक ग्रैन्यूल्स फागोसोम के साथ फ्यूजोलोमोसोम बनाते हैं। कणिकाओं में अणु होते हैं जो फागोलिसोम के पीएच को कम करते हैं, जिससे यह बहुत अम्लीय हो जाता है, और यह रोगजनकों के लगभग 2% को मार देता है। अब, न्युट्रोफिल वहाँ बंद नहीं करता है। यह रोगजनकों से भरे होने तक अधिक से अधिक रोगजनकों को निगलता रहता है, और उस बिंदु पर, यह ऑक्सीडेटिव फटने को रोकता है। ऑक्सीडेटिव फटने के दौरान, न्यूट्रोफिल हाइड्रोजन पेरोक्साइड जैसे अत्यधिक प्रतिक्रियाशील ऑक्सीजन अणुओं का उत्पादन करता है। ये अणु आस-पास के प्रोटीन और न्यूक्लिक एसिड को नष्ट करना शुरू कर देते हैं – थोड़ा सा न्यूट्रोफिल डंपिंग ब्लीच की तरह और फिर खुद को आग पर प्रकाश। यह प्रक्रिया न्यूट्रोफिल को मार देती है – आत्महत्या मिशन का एक सा – लेकिन प्रत्येक न्यूट्रोफिल इसके साथ बहुत सारे रोगजनकों को बाहर निकालता है।ट्रोफिल की तुलना में, ईोसिनोफिल और बेसोफिल बहुत कम आम हैं। उन दोनों में कणिकाएँ होती हैं जिनमें हिस्टामाइन और अन्य प्रिनफ्लेमेटरी

    How to work Immune system Organs 

    अब, न्यू अणु होते हैं। ईओसिनोफिल्स डाई ईओसिन के साथ गुलाबी दाग ​​देते हैं – जो कि उनका नाम मिलता है। Eosinophils भी phagocytic हैं, और वे सबसे बड़े और अनछुए परजीवियों से लड़ने के लिए जाने जाते हैं क्योंकि eosinophils न्यूट्रोफिल से बहुत बड़े हैं और रिसेप्टर्स हैं जो परजीवी के लिए विशिष्ट हैं। न्यूट्रोफिल और ईोसिनोफिल के विपरीत, बेसोफिल गैर-फैगोसाइटिक हैं। वे डाई हेमटॉक्सिलिन के साथ नीले रंग का दाग लगाते हैं, और ईोसिनोफिल्स की तरह, वे बड़े परजीवियों का मुकाबला करने में सहायक हो सकते हैं, लेकिन अस्थमा और एलर्जी प्रतिक्रियाओं में सूजन भी पैदा कर सकते हैं। अंत में, मस्तूल कोशिकाएं हैं जो गैर-फागोसाइटिक भी हैं और वे अस्थमा और एलर्जी प्रतिक्रियाओं में शामिल हैं। इसके बाद मोनोसाइट्स, मैक्रोफेज और डेंड्राइटिक कोशिकाएं हैं, जो फागोसाइटिक कोशिकाएं हैं – वे रोगजनकों को प्रस्तुत करती हैं, एंटीजन को प्रस्तुत करती हैं, और साइटोकिन्स को छोड़ती हैं – छोटे अणु जो क्षेत्र में अन्य प्रतिरक्षा कोशिकाओं को आकर्षित करने में मदद करते हैं। मोनोसाइट्स केवल रक्त में प्रसारित होते हैं।

    कुछ मोनोसाइट्स ऊतकों में पलायन करते हैं और मैक्रोफेज में अंतर करते हैं, जो ऊतकों में रहते हैं और रक्त में नहीं पाए जाते हैं। अन्य मोनोसाइट्स डेंड्राइटिक कोशिकाओं, प्रोटोटाइपिक एंटीजन-प्रेजेंटिंग सेल में अंतर करते हैं, जो लसीका, रक्त और ऊतक में घूमते हैं। जब डेंड्रिटिक कोशिकाएं युवा और अपरिपक्व होती हैं, तो वे फागोसिटोसिस में उत्कृष्ट होती हैं, तो लगातार अंतरालीय द्रव में पाए जाने वाले प्रोटीन की बड़ी मात्रा में खाती हैं। लेकिन जब एक डेंड्राइटिक सेल पहली बार एक रोगज़नक़ को जन्म देता है – यह एक जीवन-परिवर्तन है, जो उम्र के क्षण में आता है। परिपक्व डेंड्राइटिक कोशिकाएं रोगज़नक़ को नष्ट कर देंगी और इसके प्रोटीन को लघु अमीनो एसिड श्रृंखलाओं में तोड़ देंगी।

    डेंड्रिटिक कोशिकाएं तब लसीका के माध्यम से निकटतम लिम्फ नोड में चली जाएंगी और वे प्रतिजन प्रस्तुति करेंगे, जहां वे उन एमिनो एसिड श्रृंखलाओं को प्रस्तुत करते हैं – जो एंटीजन हैं – टी कोशिकाओं तक। एंटीजन प्रस्तुति वह है जो जन्मजात और अनुकूली प्रतिरक्षा प्रणाली को जोड़ती है। एंटीजन प्रस्तुति एक ऐसी चीज है जो डेंड्राइटिक कोशिकाओं द्वारा की जा सकती है, लिम्फ नोड में रहने वाले मैक्रोफेज, और मोनोसाइट्स जो रक्त जनित रोगज़नक़ों को फैलाने के बाद एक लिम्फ नोड की यात्रा कर सकते हैं – यही कारण है कि इन सभी कोशिकाओं को एंटीजन-प्रस्तुत कोशिकाओं के रूप में संदर्भित किया जाता है। । अब, केवल एक रिसेप्टर के साथ टी कोशिकाएं जो एंटीजन के विशिष्ट आकार को बांध सकती हैं – सक्रिय हो जाएंगी – जिसे प्राइमिंग कहा जाता है। यह समान है कि एक ताला केवल तभी खुलता है जब बहुत विशिष्ट आकार वाली एक चाबी अंदर जाती है। हालांकि, टी कोशिकाएं केवल अपने प्रतिजन को देख सकती हैं यदि यह उन्हें चांदी के थाल पर प्रस्तुत किया जाता है – और एक आणविक स्तर पर जो कि थाली है। शॉर्ट के लिए मेजर हिस्टोकंपैटिबिलिटी कॉम्प्लेक्स या एमएचसी।

    इसलिए एंटीजन-प्रेजेंटिंग सेल एक एमएचसी अणु पर एंटीजन लोड करेगा और इसे टी कोशिकाओं को प्रदर्शित करेगा – और जब सही टी सेल साथ आता है – यह बांधता है! अब अन्य समूह – लिम्फोइड पूर्वज कोशिकाएं – लिम्फोइड कोशिकाएं बन जाती हैं जो बी कोशिकाएं हैं, प्राकृतिक हत्यारे कोशिकाएं-एक नाम हुह? और टी सेल, जिनके बारे में हमने पहले ही थोड़ी बात कर ली है। बी और टी कोशिकाएं अनुकूली प्रतिरक्षा प्रणाली बनाती हैं, जबकि एनके कोशिकाएं जन्मजात प्रतिरक्षा प्रणाली का हिस्सा हैं। बी कोशिकाओं और एनके कोशिकाएं अपना विकास पूरा करती हैं जहां उन्होंने शुरू किया था – अस्थि मज्जा में, जबकि कुछ लिम्फोइड पूर्वज कोशिकाएं थाइमस में स्थानांतरित होती हैं जहां वे टी कोशिकाओं में विकसित होती हैं। लिम्फोसाइटों के सभी ऊतक और रक्तप्रवाह से अंदर और बाहर की यात्रा करने में सक्षम हैं। एनके कोशिकाएं ग्रैन्यूल के साथ बड़े लिम्फोसाइट हैं और वे वायरस की तरह इंट्रासेल्युलर जीवों से संक्रमित कोशिकाओं को लक्षित करते हैं, साथ ही वे कोशिकाएं जो कैंसर कोशिकाओं की तरह खतरा पैदा करती हैं। NK कोशिकाएँ अपने कोशिका द्रव्य को साइटोप्लाज्म में सीधे लक्ष्य कोशिका में छोड़ कर अपने लक्ष्य कोशिकाओं को मार देती हैं। इन कणिकाओं में कुछ अणु होते हैं जो टारगेट कोशिकाओं को एपोप्टोसिस से गुजरते हैं जिसे क्रमादेशित कोशिका मृत्यु कहा जाता है और कुछ जो कि फॉस्फोलिपिड से सीधे जुड़कर और छिद्र बनाकर लक्ष्य सेल की झिल्ली में छिद्र कर देते हैं।

    टी कोशिकाओं की तरह बी कोशिकाओं में भी उनकी सतह पर एक रिसेप्टर होता है जो उन्हें केवल एक एंटीजन के साथ बांधने की अनुमति देता है जिसका एक बहुत विशिष्ट आकार होता है। मुख्य अंतर यह है कि बी कोशिकाओं को एमएचसी अणु पर उन्हें प्रस्तुत करने के लिए प्रतिजन की आवश्यकता नहीं होती है, वे बस सीधे प्रतिजन को बांध सकते हैं। जब एक बी सेल एक एंटीजन के लिए बाध्य करता है जो एक रोगज़नक़ की सतह पर होता है, तो यह फागोसाइटोसिस और एंटीजन प्रस्तुति में सक्षम है – इसलिए तकनीकी रूप से, वे एंटीजन-प्रेजेंटिंग सेल भी हैं। अन्य एंटीजन-प्रेजेंटिंग सेल की तरह, बी सेल एंटीएच को एमएचसी II नामक एमएचसी अणु पर लोड करेगा, और इसे टी कोशिकाओं को प्रदर्शित करेगा। जब एक टी सेल सक्रिय हो जाता है तो यह बी सेल को एक प्लाज्मा सेल में परिपक्व होने में मदद करता है, और एक प्लाज्मा सेल बहुत सारे और बहुत सारे एंटीबॉडी का स्राव कर सकता है। आमतौर पर, एंटीबॉडी के स्तर को शिखर तक पहुंचने में कुछ सप्ताह लगते हैं। एंटीबॉडी, या इम्युनोग्लोबुलिन, बी सेल के रूप में सटीक एंटीजन विशिष्टता है जो वे आते हैं। स्रावित रूप में एंटीबॉडी केवल बी सेल रिसेप्टर हैं, इसलिए वे सीरम में प्रसारित कर सकते हैं, जो रक्त के गैर-सेलुलर हिस्सा है – रोगजनकों से जुड़ना और विनाश के लिए उन्हें टैग करना। क्योंकि एंटीबॉडी कोशिकाओं के लिए बाध्य नहीं हैं और रक्त में स्वतंत्र रूप से तैरते हैं, इसे हार्मोनल प्रतिरक्षा माना जाता है – शब्द “हास्य” जो शरीर के तरल पदार्थ को संदर्भित करता है के लिए एक थ्रोबैक। अब लिम्फोइड सेल का अंतिम प्रकार टी सेल है और सेल-मध्यस्थता प्रतिरक्षा के प्रभारी हैं।

    टी कोशिकाएं प्रतिजन-विशिष्ट हैं, लेकिन वे अपने प्रतिजन रिसेप्टर का स्राव नहीं कर सकते हैं। एक भोले टी सेल को सक्रिय किया जा सकता है या इसे किसी भी एंटीजन प्रस्तुत कोशिकाओं द्वारा एक परिपक्व टी सेल में बदलने की अनुमति दी जा सकती है, लेकिन ज्यादातर यह एक वृक्ष के समान सेल द्वारा किया जाता है। अब, दो मुख्य प्रकार की टी कोशिकाएँ हैं, सीडी 4 टी कोशिकाएँ और सीडी 8 टी कोशिकाएँ – जहाँ “सीडी” विभेदन के क्लस्टर के लिए है। प्रतिरक्षा प्रणाली में सैकड़ों सीडी मार्कर हैं, और ये सीडी मार्कर उन्हें अलग बताने में उपयोगी हैं। उदाहरण के लिए, सभी टी सेल सीडी 3 + हैं, क्योंकि सीडी 3 टी सेल रिसेप्टर का हिस्सा है। तो, CD4 + T कोशिकाएं, वास्तव में CD3 + CD4 + हैं, और इन कोशिकाओं को सहायक कोशिकाएं कहा जाता है क्योंकि वे युद्ध के मैदान में जनरलों की तरह हैं, वे साइटोकिन्स को स्रावित करते हैं जो मैक्रोफेज, बी कोशिकाओं और एनके कोशिकाओं के प्रयासों को समन्वित करने में मदद करते हैं। यदि यह MHC II अणु पर प्रस्तुत किया जाता है तो हेल्पर टी कोशिकाएं केवल अपने प्रतिजन को देख सकती हैं। CD8 + T कोशिकाएँ CD3 + CD8 + हैं, और उन्हें साइटोटॉक्सिक T कोशिकाएँ कहा जाता है क्योंकि वे लक्ष्य कोशिकाओं को मारती हैं, वास्तव में NK कोशिकाएँ इसे एक बड़े अंतर के साथ कैसे करती हैं। CD8 + T कोशिकाएँ केवल उन कोशिकाओं को मारती हैं जो MHC I अणु पर एक विशिष्ट प्रतिजन प्रस्तुत करती हैं – जो संरचनात्मक रूप से MHC II अणु के समान है, जबकि NK कोशिकाएँ विशिष्ट रूप से लगभग नहीं होतीं, जैसे वे मारते हैं। तो अब चलो फेफड़ों में एक जीवाणु रोगज़नक़ के साथ पूर्ण प्रतिरक्षा प्रतिक्रिया के माध्यम से चलते हैं। शुरू करने के लिए, बैक्टीरिया को सांस लेना होगा, अपने नाक के बालों से फिसलना होगा, वायुमार्ग में सिलिया से अतीत होगा, और फिर फेफड़ों के उपकला परत के पिछले हिस्से में घुसना होगा। एक बार जब यह फेफड़े के ऊतकों में हो जाता है, तो बैक्टीरिया विभाजित होना शुरू हो जाएगा और फेफड़े के ऊतक में एक निवासी मैक्रोफेज का सामना कर सकता है जो बैक्टीरिया को निगलेगा और साइटोकिन्स जारी करना शुरू कर देगा। वे साइटोकिन्स रक्त वाहिकाओं को टपकाकर और आस-पास के ईोसिनोफिल, बेसोफिल और मस्तूल कोशिकाओं को आकर्षित करके भड़काऊ प्रक्रिया शुरू करते हैं, जो सूजन को बढ़ाते हुए अपने स्वयं के साइटोकिन्स और कणिकाओं को छोड़ते हैं। रक्त से न्युट्रोफिल और साथ ही अस्थि मज्जा से ताजा नए लोग ऊतक में गोता लगाते हैं और लड़ाई में शामिल होते हैं। यदि रोगज़नक़ एक वायरस था, तो एनके कोशिकाएं इस बिंदु पर संक्रमित कोशिकाओं को नष्ट करने में मदद करेंगी। यह सब सहज प्रतिरक्षा प्रतिक्रिया का हिस्सा है।

    संक्रमण के इस बिंदु के आसपास, अपरिपक्व डेंड्राइटिक कोशिकाएं रोगजनकों को पचाती हैं और फेफड़े के ऊतक से पास के लिम्फ नोड में स्थानांतरित होती हैं जहां वे एक MHC II प्रोटीन पर संसाधित एंटीजन को एक भोले टी सेल में पेश करते हैं। डेन्ड्रिटिक सेल, जो जन्मजात प्रतिरक्षा प्रणाली का हिस्सा है, टी और प्रतिजन को प्रस्तुत करने पर जन्मजात और अनुकूली प्रतिरक्षा प्रतिक्रियाओं को पूरा करता है – अनुकूली प्रतिरक्षा प्रणाली का हिस्सा। कभी-कभी, यदि संक्रमण फैल रहा है, तो बैक्टीरिया डेंड्राइटिक सेल की मदद के बिना लिम्फ नोड के लिए अपना रास्ता खोज सकता है। इस मामले में, बी कोशिकाएं – अनुकूली प्रतिरक्षा प्रणाली का हिस्सा – सीधे बैक्टीरिया को फेगोसाइटोसिस कर सकता है और इसे एक भोले टी सीडी 4 + सेल में पेश कर सकता है।

    किसी भी तरह से, यदि एंटीजन टी सेल के लिए सही “फिट” है तो यह अंतर करना शुरू कर देगा और क्लोनल विस्तार से गुजरना होगा। विभेदित सीडी 4 + टी कोशिकाएँ साइटोकिन्स को मुक्त करेंगी जो बी कोशिकाओं को प्लाज्मा कोशिकाओं में अंतर करने के लिए प्रेरित करेगी जो एंटीबॉडी का स्राव करती हैं जो कि लसीका और फिर रक्तप्रवाह में जाएगी। एंटीबॉडीज रोगज़नक़ों को टैग कर देंगे ताकि फ़ागोसाइट्स उन्हें खाने में आसानी हो। एक बार फिर, इस बिंदु पर, यदि रोगज़नक़ एक वायरस था, तो सीडी 8+ टी कोशिकाएं किसी भी संक्रमित कोशिकाओं को मार देती हैं जो एमएचसी I. पर वायरल एंटीजन को व्यक्त करती हैं। समय के साथ, जैसा कि हमलावर रोगज़नक़ बंद हो जाता है, अधिकांश बी और टी कोशिकाएं। उपेक्षा से मर जाते हैं, लेकिन कुछ स्मृति बी कोशिकाओं और मेमोरी टी कोशिकाओं में बदल जाते हैं, जो भविष्य में उनकी आवश्यकता के मामले में वर्षों तक जीवित रहते हैं। तो, पुनरावृत्ति करने के लिए – प्रतिरक्षा प्रणाली में एक सहज और अनुकूली प्रतिक्रिया होती है। जन्मजात प्रतिरक्षा प्रतिक्रिया तत्काल है, लेकिन गैर-विशिष्ट है, और स्मृति की कमी है, जबकि अनुकूली प्रतिरक्षा प्रतिक्रिया अत्यधिक विशिष्ट है और सब कुछ याद करती है, लेकिन इसे शुरू होने में कई दिन लगते हैं और लगभग दो सप्ताह चरम पर होते हैं।

     

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